Day 2 :
Keynote Forum
Joel I. Osorio
RegenerAge Clinic, Mexico
Keynote: The investigation of preferred learning styles of persons living with dementia
Biography:
CEO & Founder - Biotechnology and Regenerative Medicine at RegenerAge International ™ (www.regenerage.clinic) VP of International Clinical Development for Bioquark, Inc. (www.bioquark.com) Chief Clinical Officer at ReAnima™ Advanced Biosciences (www.reanima.tech) Westhill University School of Medicine. Mexico Advance Fellow by the American Board of AntiAging and Regenerative Medicine (A4M) Visiting scholar at University of North Carolina at Chapel Hill (Dermatology) Fellow in Stem Cell Medicine by the American Academy of Anti-Aging Medicine and University of South Florida
Abstract:
As it has been previously demonstrated that coelectroporation of Xenopus laevis frog oocytes with normal cells and cancerous cell lines induces the expression of pluripotency markers, and in experimental murine model studies that mRNA extract (Bioquantine® purified from intra- and extra-oocyte liquid phases of electroporated oocytes) showed potential as a treatment for a wide range of conditions as Squint, Spinal Cord Injury (SCI) and Cerebral Palsy among others. The current study observed beneficial changes with Bioquantine® administration in a patient with a severe SCI. Pluripotent stem cells have therapeutic and regenerative potential in clinical situations CNS disorders even cancer.2-3- 7 One method of reprogramming somatic cells into pluripotent stem cells is to expose them to extracts prepared from Xenopus laevis oocytes1 We showed previously that coelectroporation of Xenopus laevis frog oocytes; with normal cells and cancerous cells lines, induces expression of markers of pluripotency.4 We also observed therapeutic effects of treatment with a purified extract (Bioquantine) of intra- and extra-oocyte liquid phases derived from electroporated X. laevis oocytes, on experimentally induced pathologies including murine models of melanoma, traumatic brain injury, and experimental skin wrinkling induced by squalenemonohydroperoxide (Paylian et al, 2016).
The positive human findings for Spinal Cord Injury, and Cerebral Palsy with the results from previous animal studies with experimental models of traumatic brain injury, respectively (Paylian et al, 2016). Because of ethical reasons, legal restrictions, and a limited numbers of patients, we were able to treat only a very small number of patients. These results indicate that Bioquantine ® may be safe and well tolerated for use in humans, and deserves further study in a range of degenerative disorders. We propose that the mechanism of action of Bioquantine® in these various diseases derives from its unique pharmacology and combinatorial reprogramming properties. In conclusion, these preliminary findings suggest that Bioquantine is safe and well tolerated on patients with Cerebral Palsy and- Spinal Cord Injury, among others. In addition to the regenerative therapy and due to the patient condition, we decided to include the Restore- Sensor SureScan5-6 . Based on the of electrical stimulation for rehabilitation and regeneration after spinal cord injury published by Hamid and MacEwan 8-9 , we designed an improved delivery method for the in situ application of MSCs and Bioquantine® in combination with the RestoreSensor® SureScan® Conclusions: To the present day the patient who suffered a total section of spinal cord at T12-L1 shows an improvement in sensitivity, strength in striated muscle and smooth muscle connection, 11 months after the first therapy of cell regeneration and 3 month after the placement of RestoreSensor ® at the level of the lesion, the patient with a complete medullary section shows an evident improvement on his therapy of physical rehabilitation on crawling from front to back by himself and standing on his feet for the first time and showing a progressively important functionality on the gluteal and legs sensitivity
Keynote Forum
Denis Gris
Université de Sherbrooke, Canada
Keynote: Comprehensive multi-parametric behavioral analysis of neuroinflammation
Biography:
Dr. Denis Gris has started his scientific career with the Master's and Ph.D. in Neuroscience at Dr. Lynn Weaver's laboratory at the University of Western Ontario. He studied the role of inflammation in spinal cord injury. He discovered that the influx of neutrophils is detrimental for recovering after spinal cord injury. Using anti CD11d antibody as a treatment, he demonstrated that animals recovered faster and better after the treatment. Also, he showed that sever spinal cord injury results in massive inflammatory reactions throughout the body leading to syndrome similar to multiple organ dysfunction syndrome. Dr. Denis Gris continued his education in Dr. Jenny P-Y Ting's laboratory as a post-doctoral fellow at the University of North Carolina at Chapel Hill. There he studied in detail mechanism of activation of innate and adoptive immune responses. In collaboration with Dr. Wen, Dr. Eitas, Dr. Allen, and other members of the laboratory, Dr. Gris studied inflammation during obesity which leads to insulin resistance; innate and adoptive responses during multiple sclerosis. In summary, his role in this laboratory was to define the role of novel family of immuno regulatory proteins (NLRs) in different human diseases. Currently, Dr. Denis Gris is a member of Immunology Program at the University of Sherbrooke and he is studying neuro-immune interactions during healthy state and disease.
Abstract:
Recently developed various automated video assessment systems that measure mouse behavior produce enormous data sets. The analysis of such multidimensional behavioral data is a difficult task. The questions such as what parameters to use and how to combine similar behavioral parameters into various categories require an application of unbiased statistical approaches. We have developed simple and at the same time powerful protocol of behavioral analysis using R programming. Using this protocol in a mouse model of multiple sclerosis we have characterized a behavioral signature of neuroinflammation. Multiple sclerosis is an autoimmune disease of the central nervous system. Recently, we have discovered an endogenous pathway that limits inflammation in a multiple sclerosis-like disease in mice. One of the key molecules of these pathways is Nlrx1 that belongs to Nlr family of proteins. Nlrs bind multiple proteins inside cells thus redirecting molecular signalling. Using state-of-the-art automated behavioral platform, we demonstrate that Nlrx1 inhibits progression of the diseases in a mouse model of MS. Furthermore we were able to construct mice with an increased predisposition to MS. These mice demonstrate the spontaneous appearance of the disease without any immunization. This model helped us to dissociate the sickness behavioral profile from the behavioral signature of neuroinflammation. We have grouped 33 behavioral activities into clusters and factors that enabled us to reveal signs of neuroinflammation within the first week after the disease induction.
In addition, we noted significant differences in the circadian rhythm of mice with the neuroinflammatory component.
In conclusion, the approach that we used in our study to analyze behavioral signature of neuroinflammation presents highly sensitive, automated, and easy-to-use tool that can be applied to evaluate progression of neurodegenerative diseases and various treatment paradigms.
- Neurology | Neurological Disorders | Novel Therapeutics
Location: Conference Hall
Session Introduction
Aubry M. Tager
Neurologix Integrative Health, Canada
Title: mTBI (mild traumatic brain injury): The neuro-metabolic effects and treatment
Biography:
Aubry M. Tager has been helping people deal with the effects of neuro-metabolic conditions for almost 20 years. He works primarily with those individuals that have suffered mild traumatic brain injuries, auto-immune conditions and ADD/ADHD as well as balance disorders .He is a Doctor of Chiropractic licensed in the U.S. (Vermont) and currently practices as a Naturopath (Doctor of Natural Medicine) in Montreal, Quebec. He is Board Certified in Integrative Medicine through the American Association of Integrative Medicine. He holds a Diplomate in Integrative Medicine and is a Board Eligible Functional Neurologist and has completed his training and is also eligible for Fellowship Status through the International Association of Functional Neurology and FNS/National University of Health Sciences in Chicago, Il. He often holds lectures and workshops on neuro-metabolic conditions. He is the author of “Under Attack: How an autoimmune condition may be sabotaging your health, and what your can do about it”.
Abstract:
The majority of mTBIs (concussion) will heal without further symptomatology within 4-6 weeks of initial trauma. When they do not respond and progress to post-concussive syndrome, there is a strong likelihood of neuro-metabolic compromise. This can come in the form of mitochondrial dysfunction/fatigue following the metabolic cascade and efflux of potassium and subsequent influx of calcium into the cell. There will be impaired glucose metabolism and a consequent decrease in energy production (ATP/ADP) which is vital to the neurologic rehabilitation and neuroplasticity of the individual.
Methodology & Theoretical Orientation: It is therefore vital to approach the changes in NMDA receptors, neuronal depolarization and changes in the blood brain barrier, in order to allow for proper healing of the glial cells and subsequent neuro0metabolic physiology following mTBI.
Conclusion & Significance: Throughout the various stages of treatment following mTBI, there are nutraceutical, nutritional and medical considerations to be applied, in order to maximize the individual’s possibility of recovery.
Recommendations: Recommendations will be made for various supplements, vitamins, minerals and dietary guidelines, as well as pharmaceutical interventions to be applied at various stages of an mTBI.
- Workshop Session
Session Introduction
Mathieu Boule
Founder at Institute IP, Canada
Title: Posturology for improved neuromechanics
Biography:
Mathieu Boule is an osteopath (COQM – 2009) and posturologist specialized in global postural reprogramming since 2002. He is, as well, a graduate of University of Montreal in education (2001). He has cumulated over 170 hours of education in Functional Neurology from IAFNR. Mat is also certified in ART (Active Release Techniques - 2007) as well as in MAT (Muscle Activation Techniques – 2007). More recently, Mathieu Boule is the founder of Institute IP, a learning playground where neurology meets movement and performance. Courses have been held in both Canada and France, at this point and soon in the USA.
Abstract:
The objective of this session is to introduce to the attendees an analysis and intervention system for improved biomechanics via stimulation of the central nervous system. Our knowledge based on the postural system has increased dramatically in the last 25 years and it is in the context of clinical Posturology that it finds applications.
The attendee will gain appreciation for the very notion of the tonic postural system, as this system is the anti-gravity system and it is functionally adapting to both internal and external constraints.
Most appreciate the role of the vestibular system in the postural matter. In recent years, it has been shown that the feet and the eyes play a significant role in posture. How all of these sensory inputs contribute to stability and mobility will be discussed.
- Normal and pathogenic postures
- Normal and pathological stance: effects
- Normal stance
- More than 90% of people present a postural imbalance
- Strain-based pathologies or various manifestations of postural disorders
- Indications for Posturology
- The tonic postural system
- The double fractal pendulum
- The main sensors
- The main computer
- The sensors: podal, ocular, dental-occlusal
- Podal: the foot as a sensor, the interview and examination, correlations
- Ocular: various etiologies, clinical signs, correlations
- Dental-occlusal: the manducation system, clinical signs
- Obstacles: surgical scars
- Pathological scarring
- Physiopathology: postural dysregulation and metabolic dysregulation
- Can a morphostatic asymmetry create pain in the locomotor system?
- Review of an experimentation presented at the 10th SIRER congress in Lyon (2005).
- Case studies: where neuromechanics meets systemic
- Descriptions of specific cases where measurements on force plate and iheart monitor are discussed.
- Young Research Forum
Session Introduction
Tamara C. McGill-Carter
Chicago School of Professional Psychology, USA
Title: Voice It Out Loud: Viewing the World through Autistic Eyes Using Assistive Technology
Biography:
Tamara (Tammi) McGill-Carter’s expertise is in Neuro-anatomy and Neuroscience with a focus on the intricate workings of the Limbic and Memory systems. Her master’s thesis surrounds Human Memory and Encoding, detailing the fundamental changes that creates as well as destroy memories. Tammi also excels in psychological theories and is currently in her final year of the Chicago School of Professional Psychology’s Educational Psychology and Technology doctorate program, due to graduate by next summer. Her dissertation’s focus centers on Autism, Theory of Mind, and Executive Functioning. Tammi’s expertise in neuro-anatomy further expanded while working with individuals with developmental disabilities/delays at several Home Health Agencies, which created several projects centering on how autism and developmental delays affect the brain.
Tammi currently holds dual bachelor’s degrees in Psychology from Indiana University Northwest in Gary and a Master’s of Arts degree from the Chicago School of professional Psychology, the concentration focus being Trauma and Crisis Intervention.
Abstract:
DeVillers and DeVillers (2014) and Iacoboni (2009) discovered that the ability for one to find their voice and actively engage in the world around them, mirror neurons take part in speech production. However, for several sets of children with verbal delays and who are non-verbal who Speech Generating Devices (SGD). The question posed is whether the devices are more effective in school settings considering the nature of communication and interactions that occur in that setting than other settings. Past researchers made convincing cases regarding the role of language development using SGD in several settings, but the one setting that has limited literature is SPG device use in the home (Thunberg, Ashlen, & Sandberg, 2011). More specifically, a child with definite understanding of their own feelings and desires, it is necessary to hear language used by them to understand what they most desire (DeVillers & DeVillers, 2014). We can observe behavior in expressing wants and needs, but the proper verbal expressions for that child’s age range can indicate the maturity of the ToM and development of the executive functioning for their stage of life (DeVillers & DeVillers, 2014). That would lead to the second case of how the child obtains the
information for a conversation. For example, when we hear someone try to get things that they want and driven by those wants, they voice and go to the place to get those wants. This approach to ToM development, therefore, focuses on the importance of learning words as labels for mental states (DeVillers & DeVillers, 2014).
What kind of language reflects or supports the developments of ToM reasoning to give researchers an understanding of the child’s maturity is what several studies seeks to answer. Recent research focused on the verbs that reflect the child's mental state (Devillers & DeVillers, 2014). Rarely do children express their own and/or another’s' beliefs until around four year of age. This study has been replicated with children who are slightly and moderately language delayed, but has not been studied with adults whom are non-verbal and severely delayed in language (DeVillers & DeVillers, 2014). Therefore, to fill the research gap, examining data provided by the population of non-verbal/severely delayed individuals using Voice Output Command Aides (VOCA’s) in either a school, home or day program setting will hopefully answer the researcher’s pressing research question.
- Video Presentations
Session Introduction
Annette Verpillot
Posturepro, Canada
Title: The neurology of posture: target the brain to fix the body
Biography:
Annette Verpillot is the founder of Posturepro, a health company specializing in body neuromechanics and Posturology. She completed her studies alongside Dr. Bricot in France. Annette has developed some of the world’s most advanced rehabilitation and injury prevention training protocols, while also creating an international Posturology training program. Her unique postural evaluation system has gained great distinction and is recognized throughout the world for addressing chronic pain, increasing strength, and increasing sports proficiency. Today, she is regarded as one of the most experienced Posturologists in North America and has had numerous opportunities to present and teach Posturology to professionals in various fields (medicine, chiropractics, dentistry, naturopathy, sports therapy and ophthalmology). She continues to recognize and address the various factors associated with global health issues and inspire open-minded professionals who wish to truly and lastingly help their clients and patients.
Abstract:
The objective of this video conference is to explain the connections between neurology and posture and provide impactful tools to fix the body by targeting the brain. It will teach how to assess postural alignment and how to correct posture with the help of the neurological system. By addressing the neurology of posture, difficulties that stem from either the brain or the body’s sensors can be rehabilitated.
This video will begin with a description of the neurological workings of the postural system. Posture is an outcome of the unconscious processes of the neuro-musculo-skeletal system. The brain receives information from entry points to the somatosensory system, such as the soles of the feet and the eyes, to then output a posture adapted to the body’s environment. Thus, by working on these entry points, it is possible to improve the information input to the brain and ultimately maximize the output to the rest of the body.
This video will then include instruction on how to easily determine one’s posture, by way of sagittal, frontal and the transverse plane assessments. Closer inspection of arm/ leg length discrepancy, scapular/ pelvic tilt, rotation of the pelvis, and the use of a plum line will all help identify postural misalignments. Such misalignments can lead to injury and pain. When the body is misaligned, it cannot perform optimally and a ‘wearing down’ can occur.
This presentation will provide the tools necessary to address these symptoms and re-establish optimal alignment. Correction protocols including eye exercises for eye convergence and indications for shoe sizing/fit will allow attendees to improve the information coming from the somatosensory system and help the brain output an aligned posture. Our global posture is often overlooked during rehabilitation or when addressing symptoms such as pain, but a good brain-body connection is key for injury and disease prevention.
Biography:
I am a neuroscience researcher not affiliated by medical school or university nevertheless; I am a natural neuro researcher based on traditional technique as well as collaborate with modern knowledge based support.
Abstract:
As we all know that brain is one of the mysterious complex subject similar like the universe. The more we continue the feasibility study of neuroscience, the new mysterious things comes on and on which is unlimited, however constant research concerning neuroscience is my extreme passion. The present most challenging issue concerning neuroscience and neuro-immunology has been difficult to detect Alzheimer’s disease diagnosis. However, there are not yet any drug discovery relevant to AD nevertheless, after my groundbreaking discovery relevant to peripheral and central nervous system new truth theory. By correlating with that truthful theory based idea, I had designed a robotic neuro modulation technique (NMT) robotic device which role could be neuroplasticity or amyloid beta secretes removal in order to treat AD and some other neurodegenerative disease; whereas the NMT equation is HBBH = (TITT×T2s)ON.